In the past three years, the Reh lab used a combination of approaches to discover additional factors that could (1) increase the efficiency of neural production from adult mouse Müller glia and (2) specifically direct the Müller glia to regenerate new ganglion cells. These two different factor combinations can regenerate new neurons that resemble several different types of ganglion cells, at a very high efficiency; however, they do not fully mature, or send axons to the optic nerve. Therefore, this project aims to further improve the regeneration of ganglion cells from Müller glia.
Investigators
Thomas Reh, PhD
University of Washington
Thomas Reh, PhD
University of Washington
Current Stage
Discovery
In Vivo Proof of Concept
IND Enabling
Clinical Trial Phase 1
Clinical Trial Phase 2
Clinical Trial Phase 3