Retina Regeneration in Zebrafish – Endogenous RGC Replacement

Müller glia are a source of multipotent retinal progenitors that regenerate retinal ganglion cells in the zebrafish retina and understanding of the mechanism underlying this process in zebrafish will inform us of strategies for stimulating a similar process in mammals and provide a therapy for people suffering from blinding eye disease, like NF1-OPG associated vision loss. This project proposes to identify the molecular mechanisms underlying retina regeneration in zebrafish and investigate if these mechanisms can be used to stimulate retina regeneration in mammals.