Archives:
Development of Genetically Engineered Mouse Models for NF1-associated Optic Pathway Gliomas
To facilitate the translation into clinical practices, the Zhu lab will employ two clinically relevant assays to characterize these NF1-OPG models, the optomotor response (OMR) …
hiPSC Modeling of NF1 High-Grade Glioma
This project aims to generate models of malignant brain tumors (gliomas) seen in adults with NF1. Using human cells with the capacity to form every …
Creating NF1/CDKN2A/ATRX Models for NF1 Associated High Grade Glioma
Even though the frequency of high grade glioma (HGG) is low, they have an disproportional effect on the morbidity of NF1 patients. Recent studies have …