Archives:
Disrupting FBXW11-mediated degradation of NF1 to rescue haploinsufficiency
Studies in NF1 mouse models have revealed that these animals develop learning and behavioral problems similar to human patients and thus provide a valuable resource …
Development of a peptide that restores the mutant NF1-Ras interaction
This project focuses on the development of a new strategy for the treatment of NF1. The pathology of NF1 disease primarily originates from the broken interaction …
NF1 RNA Repair Based on Therapeutic Ribozymes
Ribozymes, ribonucleic acid (RNA) molecules with catalytic properties can be modified to specifically bind to a target RNA of choice, split this RNA at a …