Stem Cell Derived RGCs: Improving the Success of Transplantation Strategies

This project aims to advance vision restoration using exogenous RGC transplantation in NF1-OPG mice by 1) generating and then using an immuno-incompetent strain of the …

Human Stem Cell-Derived RGCs for Optic Nerve Regeneration

In the first phase of the VRI the Zack lab optimized their method to generate human RGCs from human stem cells and provided these to …

RGC Differentiation and Transplantation for NF1 OPG

This project aims to increase our understanding of how to generate human RGCs for transplant, and benefit stem cell-based therapy for vision restoration in NF1 …

Vision Restoration in Neurofibromatosis: Donor RGC Response to Microenvironment

The goal of this project is to study the response of donor RGCs to host NF1 microenvironment and to modulate the latter to allow stem-cell-derived …

Stem Cell Derived RGCs: Improving the Success of Transplantation Strategies

Our overall goal in this project is to improve the success of RGC transplantation, using mouse cells, together with tissue engineering and pig-to-pig transplantation studies. …

Human Stem Cell-Derived RGCs for Optic Nerve Regeneration

Neurofibromatosis type 1 (NF1) is the most common genetic condition in which individuals carrying the mutation are predisposed to develop a variety of types of …

RGC Differentiation and Transplantation for NF-1 OPG

The optic neuropathy and vision loss seen in optic glioma (OPG) in some cases associated with neurofibromatosis type 1 (NF1) afflicts the eye and leads …